Isa peace be upon him was explicitly mentioned in the Holy Quran on sixteen different occasions. On one occasion Allah the Exalted said in Surat Al-Maidah verse 110
( (remember) when Allah will say( on the day of resurrection ).”O Isa(Jesus), son of Mariyam(Mary)! Remember my favor to you and to your mother when I supported your with ruh -u- qudus [ Jibrail (Gabril)] so that you spoke to the people in the cradle and in maturity; and when I taught you writing, Al Hikmah(the power of understanding), the Taurat(Torah) and the Ingil( Gospel); and when you made out of the clay, a figure like that of a bird, by my permission, and you breathed into it, and it became a bird by my permission, and you healed those born blind, and the lepers by my permission, and when you brought forth the dead by my permission; and when I restrained the children of Israel from you ( when they resolved to kill you) as you came unto them with clear proofs and the disbelievers among them said: “This is nothing but evident magic” ﴿ )
On the other hand Prophet Mohammad peace be upon him was explicitly mentioned in the Holy Quran four times While the Virgin Mary (peace be upon her) the mother of Jesus(Isa) was mentioned eight times and has a complete Sura (chapter) named after her.
On one occasion Allah the All Mighty said in Surat Al- Imran verse 145:
( (remember) when the angles said: ” Oh Mariyam (Mary)! Verily, Allah gives you the glad tidings of a word["Be!"- and he was! i.e.' Isa ( Jesus) the son of Mariyam( Mary) ] From him his name will be the Messiah ‘Isa (Jesus) the son of Mary ( Mariyam), held in honor in this world and in the hereafter, and will be one of those who is near to Allah.)
As a family they have been mentioned in the Holy Quran three times and they have been privileged by having a complete Sura(chapter) named after them(Al Imran). Which is imprinted in the hearts and minds of the believers forever.